GENETIC STUDIES ON AMETHOPTERIN RESISTANCE IN DIPLOCOCCUS PNEUMONIAE

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Dihydrofolate Reductase in Genotypically Distinguishable Amethopterin-resistant Diplococcus Pneumoniae.

Mutation to amethopterin(4-amino-lo-methylpteroylglutamic acid) resistance in Diplococcus pneumoniae has been shown (1) to occur in two distinct and remotely situated regions of the deoxyribonucleic acid. Comparative growth and cross-resistance studies, also reported at that time, suggested that these genetic regions were also biochemically distinguishable. During investigations seeking to iden...

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Alteration in Transformability of Diplococcus Pneumoniae after the Acquisition of Genetic Determinants Inducing Resistance to Erythromycin.

Sirotnak, Francis M. (Sloan-Kettering Institute for Cancer Research, New York, N.Y.), Ramona B. Lunt, and Dorris J. Hutchison. Alteration in transformability of Diplococcus pneumoniae after the acquisition of genetic determinants inducing resistance to erythromycin. J. Bacteriol. 86:735-739. 1963.-The genetic alteration of a highly transformable (competent) recipient strain of Diplococcus pneum...

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Neuraminidase activity in Diplococcus pneumoniae.

Kelly, R. T. (Marquette University School of Medicine, Milwaukee, Wis.), D. Greiff, and S. Farmer. Neuraminidase activity in Diplococcus pneumoniae. J. Bacteriol. 91:601-603. 1966.-A method for the quantitation of neuraminidase in the presence of N-acetylneuraminic acid aldolase is described. The neuraminidase content of Diplococcus pneumoniae was found to be dependent on the media employed for...

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Population changes in Diplococcus pneumoniae.

Carta, G. (Wesleyan University, Middletown, Conn.) and W. Firshein. Population changes in Diplococcus pneumoniae. J. Bacteriol. 84:473-477. 1962.-Avirulent mutant strains derived from pneumococcal types I, II, III, and VII established themselves in initially virulent or predominantly virulent populations within 36 to 48 hr of incubation at 37 C in Brain Heart Infusion-blood broth. Aged blood-br...

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Structural studies of capsular polysaccharide of type XII Diplococcus pneumoniae.

The capsular polysaccharide of Diplococctw pneumoniae Type XII contains residues of D-glucose and D-galactose in a molar ratio of 2:l. The methylated polysaccharide yielded upon hydrolysis 2,3,4,6-tetraand 3,4,6-tri-O-methyl-D-glucose and 2,3,4,6-tetra-0-methyl-D-galactose as the only neutral methyl sugars. Periodate oxidation of the polysaccharide resulted in destruction of all neutral sugars ...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1960

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.80.5.648-653.1960